Supplements
Evidence reviews of longevity supplements: NAD+ precursors, senolytics, adaptogens, and more.
Microbiome-directed interventions for longevity
How probiotics, prebiotics, diet, and microbiome transplantation may influence aging through the gut-immune-brain axis.
mTOR modulation and caloric restriction mimetics
How rapamycin and related compounds shift cellular behavior from growth toward repair, and the evidence for anti-aging effects.
NAD+ and aging: the complete evidence review
What the research actually shows about NAD+ precursors, which forms work, optimal dosing, and what the clinical trials say about real outcomes in humans.
NAD+ restoration: precursors, pathways, and evidence
How NMN, NR, and other NAD+ precursors work, what the human trials show, and where the gap between biomarker and outcome data stands.
NMN vs NR: which NAD+ precursor has better evidence?
Comparing bioavailability, clinical trial data, and cost-effectiveness of the two main NAD+ boosters.
Partial epigenetic reprogramming: reversing cellular age
How OSK-based reprogramming factors may restore cellular identity without full dedifferentiation, and where human translation stands.
Plasma exchange and circulating factor interventions
How blood-borne factors may influence tissue aging, what parabiosis research revealed, and where plasma-based approaches stand.
Senolytics: clearing the cells that accelerate aging
How senolytic compounds like dasatinib, quercetin, and fisetin target senescent cells, and what the human evidence shows so far.
Telomere-related interventions: promise and caution
Approaches to preserving or extending telomere function, why direct telomerase activation remains risky, and what is credible.